There is hardly a clinical picture that is as unclear as Morgellons disease. The level of suffering of the patients (predominantly female) is considerable and they need therapy. They are psychologically oversensitive and fixated on the symptoms. Antipsychotics do not really help them. On the basis of twelve female patients, the author has developed a mixed naturopathic and pharmacological therapy that has proved successful and is presented here. It is based on the aetiological hypothesis of widespread subcutaneous fungal mycelia that live in symbiosis with other pathogens or parasites.

50 year old woman presented with progressive breathlessness for 5 days. For last 1 day she was severely dyspnoic. We diagnosed this case as a Covid Myo-pericarditis with severe pulmonary hypertension and atrial fibrillation on the basis of pulse 110 bpm, irregularly irregular, BP-90/60 mm of Hg, Lungs- bilateral crepitation, altered with coughing with diminished breath sound, ECG-Atrial fibrillation with fast ventricular rate and echocardiographic findings like severe global hypokinesia with severe LV systolic dysfunction, thickened myocardium and pericardium with severe pulmonary hypertension. Later RT PCR became positive, Troponin I and Pro BNP were raised, HRCT chest reveals mild pulmonary involvement with thickened pericardium and treated accordingly.

Introduction: Diabetes mellitus is a significant global health concern, with an increasing prevalence worldwide. One of the most severe complications of diabetes is lower limb amputation, which has devastating physical, psychological, and socioeconomic consequences for patients. Understanding the frequency and associated factors of lower limb amputation among diabetic patients is crucial for developing targeted prevention and management strategies. Methods: A quantitative observational cross-sectional study was conducted to determine the frequency of lower limb amputation and associated factors among 300 diabetic patients in three selected hospitals in Mogadishu, Somalia from July 2022–November 2023. Demographic characteristics, clinical data, and amputation-related information were collected through patient interviews and medical record reviews. Results: The study found that 57% of the participants were male, and the majority (50%) were aged 41-65 years. The main reasons for amputation were diabetic foot ulcers (67%) and peripheral arterial disease (33%). The overall frequency of lower limb amputation was 35%. Factors associated with amputation included older age, male gender, longer duration of diabetes, poor glycemic control, and the presence of diabetic complications like neuropathy and peripheral arterial disease. Discussion: The high frequency of lower limb amputation among diabetic patients in this study highlights the need for a multifaceted approach to diabetes management, including early detection and prevention of complications, prompt wound care, and a multidisciplinary team-based approach. Rehabilitation and psychosocial support are also crucial to improve the quality of life for amputees.

Since the 1940s, antimicrobials have been used to combat microbial infections and sickness enormously. However, due to the overuse and abuse of antimicrobials, antimicrobial resistance has been exacerbated resulting in side effects. The microbes have developed resistant mechanisms towards antimicrobials making these drugs less effective (Soni, 2014). Antimicrobial resistance reduces the effectiveness of an antimicrobial in curing a disease or condition. In order to combat the increasing rate of antimicrobial resistance, new strategies are needed; hence researchers are looking into using combination therapy to combat AMR. This research envisages treating infections with different combinations and/or sets of drugs rather than individual drugs. Nucleoside analogues are commonly used for treating viral and fungal infections, as well as for treating cancers, however, a significant number of clinically approved derivatives of both pyrimidines and purines have been shown to have antibacterial activity. In view of this, this experiment will be conducted to determine the drug interactions between the methylxanthines and antimicrobials to find out their potential antimicrobial properties in an attempt to repurpose these drugs. The method employed includes drug preparation and antibiotic/fungal preparations, determination of their minimum inhibitory concentration and the determination of their drug interactions with the antimicrobials by disc diffusion bioassay. For the results, it is envisaged that interactions between the xanthine-based drugs and the antibiotics or antifungals may potentiate the activity, have no significant effect on the activity and/or suppress the activity of antibiotics and antifungals against the selected bacterial and fungal culture.

Background: Hyperlipidemia is a condition where the body has increased levels of lipids, or lipoproteins. Our bodies' main circulating lipid particle is cholesterol. The Mevalonate pathway is the biosynthetic route used for cholesterol, and it is found in the liver.1 This Mevalonate pathway results in cholesterol. The manufacture of cholesterol is aided by a number of enzymes. A variety of enzymes, including HMG-CoA synthase, HMG-CoA reductase, Farnesyl PP synthase, Lanosterol synthase, and Squalene synthase.2 The cholesterol-lowering drug lovastatin was first discovered in a strain of Aspergillus terreus with the chemical formula C24H36O5 and IUPAC Name: (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl (2S)-2-methylbutanoate.3 In persons who have heart disease or who are at risk of developing heart disease(cardiovascular disease), lovastatin, a popular HMG-CoA reductase inhibitor, is used along with diet, weight loss, and exercise to lower the risk of heart attack and stroke and to lower the likelihood that heart surgery would be required.4 Due to adverse effects of lovastatin, such as a consistent rise in serum ALT and AST, GI distress, and dizziness, a new lovastatin derivative with limited adverse effects and high efficacy is required.5 Objective: The goal of the current research employed computational methods like docking and in silico ADMET analysis to identify novel lovastatin derivative compounds as HMG-CoA reductase inhibitors with a higher binding affinity as compared to the standard drug lovastatin. Methods: Virtual screening was used to create molecules, which were then molecular docked with all developed compounds and subjected to ADMET analysis on compounds that were successful. Results: Utilising virtual screening, compounds were created, and AutoDock Vina 1.5.6 was used for molecular docking in the lovastatin binding site (PDBID: 7CPX) (The active site of HMG-CoA reductase).6 Seven powerful hits from docking studies were subjected to SwissADME's ADME analysis. Seven substances with the best ADME profiles and greater bioavailability were predicted by ADME analysis. Conclusion: Exploring the fields of computational and medical research will be made possible by this research work in great detail. Due to this, future experimental investigations with HMGCoA reducatse inhibitors will be made easier to develop.

Background: Acrylic resin is the most common material used as a denture base that contacts directly with the oral mucosa. Acrylic resin has a porous surface and surface roughness that allow the attachment and formation of Candida albicans colonies that trigger denture stomatitis. Bilimbi (Averrhoa bilimbi L.) juice contains saponins, phenols, tannins, alkaloids, flavonoids, and triterpenoids, which have antifungal activity against Candida albicans. Purpose: To determine the effectiveness of bilimbi juice on the growth of Candida albicans on heat-cured and cold-cured acrylic resin. Material and method: Experimental laboratory research with a post-test only control group design. 24 heat-cured and cold-cured acrylic resin samples, sizes 10x10x2 mm were divided into 4 groups. Groups I and II were heat-cured and cold-cured acrylic resins immersed in 100% bilimbi juice. Groups III and IV were heat-cured and cold-cured acrylic resins immersed in Aqua®. Each group was immersed for 48 hours, and then the number of colonies was calculated. Results: There was a significant difference in the amount of Candida albicans in heat-cured and cold-cured acrylic resins immersed in 100% bilimbi juice compared with Aqua® (p < 0.05). Conclusion: Bilimbi juice is effective in decreasing the growth of Candida albicans on heat-cured and cold-cured acrylic resins.

The integration of artificial intelligence (AI) in medication delivery systems holds significant promise for enhancing efficiency, reducing costs, and improving patient outcomes in North America. This paper explores the potential of AI-driven solutions, such as chatbots and large language models (LLMs), to transform the pharmaceutical supply chain. By leveraging advanced technologies like cloud computing and big data analytics, healthcare providers can streamline operations, optimize distribution networks, and ensure timely access to medications. This study reviews existing literature, identifies key challenges and opportunities, and proposes a comprehensive framework for implementing AI in medication delivery. The findings underscore the critical role of AI in achieving a resilient and responsive healthcare supply chain.

Plant-derived materials and herbal medicines are gaining a lot of attention these days because of their many uses, as plants with medicinal properties are the primary supplier of the bioactive substances used in traditional as well as contemporary medicine. Even in places where availability of modern medicine is available, there has been a notable increase in interest in and utilization of herbal remedies in recent years. There is a need for effective pain and inflammation treatment in today's world. Investigations into herbal formulations from natural sources are needed to find new treatment solutions. Assessing the analgesic and anti-inflammatory properties is the current study's objective along with pharmacological screening methods and the herbal formulations. The herbal preparations used in the aforementioned studies provided excellent discomfort and swelling prevention in test animals. The aforementioned pharmacological impacts may be attributable to the presence of phytoconstituents present in the formulations.

Objective: To determine the association between hypertensive disorders and pregnancy outcomes. Study Design: Cross-sectional study. Study Location: Benazir Bhutto Hospital, Rawalpindi. Study Duration: 1 month. Methods: The study was conducted in the Department of Gynecology from November 15, 2023, to December 15, 2023. Data were collected from 18 pregnant women using a revalidated questionnaire. The data were then entered into SPSS for analysis. Results: The results showed a significant association between pregnancy-induced hypertension and certain pregnancy outcomes. Parameters such as maternal age, mean blood pressure (BP), mode of delivery, and birth weight of babies were assessed and showed varied results. Pregnant women at higher extremes of age had a greater prevalence of elevated mean blood pressures. Additionally, the results indicated that the higher the maternal age, the higher the likelihood of having a C-section and elevated mean blood pressures. Most babies born had a mean birth weight of around 3 kg. However, birth weight did not show a significant association with BP. Conclusion: Hypertensive disorders of pregnancy (HDP) are influenced by various factors, with older maternal age and obesity being the most common. The incidence of hypertensive disorders of pregnancy varies based on race, socioeconomic status, age, and parity. Creating awareness of the risks associated with hypertensive disorders of pregnancy is essential. Pregnant women with hypertensive disorders require frequent antenatal visits to ensure appropriate outcomes.

Background: Cameroon has high rates of sickle cell disease (SCD) attributed to lack of awareness among the reproductive age in the country. In Cameroon, the prevalence of SCD is 18.2% for the heterozygous form and 2.3% for the homozygous (HbSS) forms. Objective: This study determined the knowledge, attitude and practices of premarital counseling for sickle cell disease (PMCSCD) amongst Council workers of the Tubah, Bamenda I, II, III and City Council of North West Region of Cameroon, to see how this knowledge can be translated to intending couples to improve marital outcomes. Materials and method: A community based cross sectional study design with purposive random sampling was used to select Council workers who participated in the study. Data was generated by use of semi-structured questionnaires and presented using frequency, percentages and charts. Descriptive analysis was done using statistical package for social sciences (SPSS) software version 21. Relationship between variables was assessed using Chi-Square Test. We used a P-value of <0.05 as a cut off point for statistical significance. Results: A total of 59 respondents filled the survey. The result shows that knowledge of PMCSCD varied from one aspect to another, with an overall poor level. Attitude of respondents towards PMCSCD remained good (54.2%). Meanwhile implementation of PMCSCD in participants life was grossly inadequate (96.6%), with apparently no premarital counselor for SCD in any of the councils as reported by 83.1% of study participants. Out of the sociodemographic characteristics of interest, level of education was found to be significantly associated with knowledge (X2=17.5; P= 0.04). The survey also found a significant association between participants attitude and sex, age group and marital status. No sociodemographic factor was found to be associated with practice. Conclusion: Overall, council workers had poor knowledge of PMCSCD. Attitude of workers towards PMCSCD was good. Practice of PMCSCD among study participants remained poor. This suggests that council authorities should take advantage of this information and pull attention to potential areas for intervention and improvements in knowledge of man power resources especially true in relation to sickle cell disease counselor so that the knowledge can be translated to intending couples to foster better outcomes in sickle cell prevention, awareness and management.

Toxoplasma gondii (TG), Rubella virus (RV), cytomegalovirus (CMV), and herpes simplex virus types 1 and 2 (HSV 1 and 2) are generally mild in immunocompetent adults, but can lead to serious complications for the fetus and newborn when they occur during pregnancy. This study aims to determine the seroprevalence of these infections in pregnant women, commonly referred to by the acronym TORCH, by analyzing their serological profile in IgM and IgG. To achieve this, 83 samples were obtained from two collection sites in Yaoundé from the serological bank of the Microbiology Laboratory of the University of Yaoundé 1 and analyzed. The One Step Rapid Test Kit from EVANCARE was used. The survey sheets accompanying the plasma samples were used to associate the risk factors in this population. The results obtained regarding the IgG seroprevalence of TORCH infections in our samples were as follows: Toxoplasmosis IgG 34.9%, Rubella IgG 28.9%, Cytomegalovirus IgG 28.9% and HSV1 IgG 30.1%. Only HSV1 showed an IgM seropositivity (1.2%). These results were totally negative for both HSV2 IgM and HSV2 IgG testing. Factors associated with the acquisition of these pathogens and the production of IgG antibodies were: urban area of residence, contact with soil, consumption of raw or undercooked meat, contact with domestic animals, the last two trimesters of pregnancy, and blood transfusion. This study contributed to a better understanding of the prevalence and risk factors of TORCH infections in pregnant women in Yaoundé.

Fenton's naviculo-capital syndrome or scapho-capital fracture is a very rare lesion, often overlooked. It results from high-energy wrist trauma. Its mechanism is controversial. It is most often associated with carpal dislocation. Forced extension appears to be the most frequent etiology; fracture of the scaphoid by compression makes hyperextension of the wrist possible, thus allowing contact between the posterior horn of the lunate and the proximal pole of the capitate which is fractured and tilted from 180°. The dorsal approach allowed a reduction of the capitate as well as contention by pinning the first row, independently of the second row. The scapholunate and lunaro-triquetral interosseous ligaments were intact. The anterior approach allows a good reduction of the scaphoid while preserving its vascularization. An antebrachiopalmar cast immobilization was put in place for 12 weeks. The rehabilitation lasted six months. Two years later, the Cooney functional score was good and all the fractures had healed without any intracarpal misalignment. Return to work was in the eighth months after the accident. Conclusion: Hypertensive disorders of pregnancy (HDP) are influenced by various factors, with older maternal age and obesity being the most common. The incidence of hypertensive disorders of pregnancy varies based on race, socioeconomic status, age, and parity. Creating awareness of the risks associated with hypertensive disorders of pregnancy is essential. Pregnant women with hypertensive disorders require frequent antenatal visits to ensure appropriate outcomes.