There is hardly a clinical picture that is as unclear as Morgellons disease. The level of suffering of the patients (predominantly female) is considerable and they need therapy. They are psychologically oversensitive and fixated on the symptoms. Antipsychotics do not really help them. On the basis of twelve female patients, the author has developed a mixed naturopathic and pharmacological therapy that has proved successful and is presented here. It is based on the aetiological hypothesis of widespread subcutaneous fungal mycelia that live in symbiosis with other pathogens or parasites.