The main word formation of immunological terminology include compounding, derivation, abbreviation, and terminologization. Based on these word-formation principles, the translation of immunological terms should strictly follow the three requirements, i.e. conceptual accuracy, standardized term and contextual appropriateness. Based on the deep analysis of the context, translators should convey the accurate specialized knowledge and reproduce the translated term according to the writing convention of the target language. These translation requirements help translators to achieve the accuracy and appropriateness of terminology translation in immunological literature.