Anemia is a condition where the number of red blood cells or hemoglobin concentration in it is lower than normal. The group design of this research subject is anemia patients with Systolic hemoglobin levels <12 mg/dL which are divided into 4 treatment groups, namely groups P0, P1, P2, P3. The doses given were P0 leaflet education, P1 100gr hatkam nuggets and leaflet education, P2 100ml probiotic red guava juice and leaflet education, P3 100gr hatkam nuggets and probiotic red guava juice and leaflet education. The intervention was conducted for 7 days. Hemoglobin levels were measured using easy touch, checking hemoglobin levels before and after the intervention. Normality test was conducted using Shapiro-Wilk. Statistical analysis using ANOVA test and followed by Duncan test. The results showed that the average hemoglobin levels before intervention P0 11g/dL, P1 10g/dL, P2 10g/dL, P3 9g/dL. The average hemoglobin levels in the anemia group after intervention P0 12g/dL, P1 13g/dL, P2 14g/dL, P3 17g/dL with Systolic hemoglobin levels P-value = 0.000. Of the 4 treatments, the best treatment is the P3 treatment. It can be concluded that there is an effect of giving chicken liver and red bean nuggets (hatkam) and probiotic red guava juice on hemoglobin levels in anemic adolescent girls with anemia at Ma Hidayatul Qomariah Bengkulu City.