Introduction: Postpartum depression (PPD) is a significant mental health issue affecting women after childbirth, with implications for maternal and infant well-being. Despite its global prevalence, there is a lack of research on PPD in certain regions, including Somaliland. This study aims to fill this gap by investigating the prevalence and associated factors of PPD among mothers attending healthcare facilities in Borama, Awdal, Somaliland. Background: PPD is characterized by depressive episodes occurring after childbirth, affecting approximately 13-19% of postpartum women globally. Social stressors such as poverty, intimate partner violence, and unintended pregnancy contribute to the risk of PPD, making it a significant public health burden. Understanding the prevalence and factors associated with PPD is crucial for informing diagnosis, interventions, and policy measures. Methodology: This study employed an institution-based descriptive cross-sectional study design, focusing on mothers who gave birth and received postpartum care in selected healthcare facilities in Borama, Somaliland. A total of 300 mothers were recruited for the study using systematic random sampling. Data was collected using a structured questionnaire covering socio-demographic, obstetric, and social support factors, as well as the Edinburgh Postnatal Depression Scale (EPDS) to assess PPD. Descriptive statistics and chi-square and logistic regression for data analysis. Results: The study found a prevalence rate of 35.4% for PPD among mothers attending healthcare facilities in Borama, Awdal, Somaliland. Factors such as age of marriage, employment status, type of employment, and monthly income were significantly associated with PPD. Younger age at marriage was linked to a higher likelihood of experiencing PPD, while employment appeared to have a protective effect on maternal mental health. Recommendations and Conclusion: Based on the findings, recommendations include developing targeted support programs for younger mothers, promoting workplace policies that support maternal mental health, integrating mental health services into routine maternal care, and launching community awareness programs to reduce stigma. Addressing these factors can contribute to improved maternal mental health outcomes and overall well-being for mothers and their infants. In conclusion, this study underscores the importance of understanding and addressing the complex factors influencing PPD to support maternal and infant health in Somaliland.