The success of metal materials in their use is very much one of them in medical applications. Metal material is a material that is mostly composed of transition elements and tends to provide high resistance to structures and other properties. The ability of various metal materials has great potential to be applied as drug delivery. Metal-material designs were developed to overcome the problem of poor chemical stability and other advantages as drug delivery. Various methods have been carried out by incorporating metal ions in drugs, or using metal-based materials as direct drug delivery. Studies mention that metal-material-based drug delivery can have its own advantages for the body when degraded and has high resistance in drug storage.