Humanity is facing one of the worst moments in its history with the spread of the New Coronavirus on a global scale. The aim of this research was to find out the perspectives of micro and small entrepreneurs in relation to the following factors: e-commerce and online transactions; distribution chains and sales cycles, as well as economic aspects. To this end, a quantitative/exploratory study was carried out within a pre-established time frame. A bibliographical study was carried out in order to contextualize the theme and form the theoretical framework that underpins the research. The data was collected through observation and the application of a structured questionnaire to a given population of micro and small companies in Brazil. The research is justified by the need to elucidate investigations into the survival of Micro and Small Enterprises - MSEPs. It is hoped that this work will provide useful information for MSEP entrepreneurs, as well as serving as a reference for those who intend to use the information contained in this research for future work. It can be inferred that information about the environment is scarce and entrepreneurs only become aware of the changes taking place in their respective sectors when they are already underway. They react to the changes by introducing new technologies, training their human resources, improving the quality of their products and adopting competitive prices.