This study analyses the influence of economic diplomacy and digitalization on enhancing diplomatic relations for Sub-Saharan economic development growth, with a focus on Tanzania's interactions with other countries in the region. A descriptive research design was utilized, involving the development of a questionnaire that addressed specific issues, with responses measured on a 5-point Likert scale. The data was collected through its administration to 288 employees of the protocol department at the Ministry of East African Foreign Affairs and International Cooperation with 276 responses being utilized. The Cronbach’s Coefficient Alpha method was employed to assess the internal consistency of the research instruments, revealing that all variables achieved a reliability scale exceeding 0.7, which is deemed acceptable. Following the successful analysis of the data collected through regression, the study's objectives were achieved. The findings of this study indicate that the digital transformation of diplomacy have facilitated interaction and collaboration between Tanzania and other Sub-Saharan countries. This study concludes that digital diplomacy are essential for advancing bilateral relations, as diplomatic transformation has evolved alongside technological advancements. The study recommends that governments should leverage the internet and technology to enhance their responses and develop increasingly secure systems, implementing the appropriate technological tools for stronger protection.