We are living in the End Times of this world in which we all are rounded by various conflicts throughout globe. Out of these conflicts Israeli-Palestine war is one, the conflict zone is located in eastern Mediterranean region. The conflict between Israel (Jews) and Palestinian (Muslims) were rooted in historical animosity and territorial disputes. The present research paper is endeavouring to attempt the information about the main reason behind the Conflict of Israel and Palestine and Human Rights Violation in Palestine. The present scenario of conflict is on its peak, the human rights violation, poverty, deaths, injury, malnutrition and many other negative effects are on its acme. To overcome from these violations and tension between Israeli-Palestine, the peace building measures are important and need of hour.