The study aimed to explain the chemistry of groundwater and assess its suitability for drinking and irrigation purposes for people living within and around the Domasi Irrigation Scheme. The dominance of cations in the Domasi Irrigation Scheme was in the order Na > Ca > Mg > K and that for anions was HCO3 > Cl > CO3 > SO4 >NO3 > F. The study revealed that the groundwater for the study area is predominantly of sodium-bicarbonate type due to weathering, cation exchange and other anthropogenic activities. The groundwater was generally suitable for drinking based on Malawi standards but with elevated levels of bicarbonates, sodium, chloride and total hardness. In the absence of a piped-treated water system in the area, there is a need to introduce water treatment technologies such as water softening. The groundwater in this area is suitable for irrigation purposes but with some caution to balance levels of magnesium and calcium with organic and inorganic fertilizers. The study advocates for the use of pumping technology to use groundwater for irrigation purposes during the dry season to maximize agricultural productivity. There is a need for a specific study to be done to look at the soil chemistry of the area so that more appropriate crops might be identified to diversify agriculture in this area. This will ensure proper and maximum utilization of both soil and groundwater for this agricultural area.