Background: Kerala has highest prevalence of thyroid disorders in India and each year the number of cases are increasing. The scope of homoeopathy in nodular goitre is studied for a safe and effective treatment option. Objective: This review was done to explore the strengths of homoeopathy in the management of Nodular goitre through published articles and literature search. Methods: A search was made for homoeopathic management of nodular goitre in PubMed, Central Council for Research in Homoeopathy e-library, Cochrane, and Google Scholar. The basic search terms included ‘Homoeopathy’ and ‘MNG’, ‘Goitre’, ‘Multinodular goitre’. The searched results screened with inclusion and exclusion criteria. Further, literature review, through homoeopathic repertories, was also conducted for finding frequently used homoeopathic drugs used in the management of goitre. Results: Through an online search, 5 case reports were found related to the subject. This shows the possibility of homoeopathic treatment in nodular goitre and there is literature evidence of medicines effective for thyroid disorders in homoeopathic repertories. This review can help the readers to narrow down the available studies and find scope for further studies. Conclusion: At present, only case reports have been published for the last decade showing benefits of homoeopathy in nodular goitre. Further well-designed studies are warranted.