Based on the fact that if present graphene in vials of nanolipids of biopharmaceutical the aspects must to be coloured the reported findings by some independet researcher of graphene like particle in viasl of m Rna covid-19 vaccine seem to suggest that this impurity can be present only inside the nanolipids. The production fo this encapulated biotecnological product imply the mixing of an acqueos phases (mRna ) with an lipidic phases (nanolipids). The graphene finded as reported, probably due by purification steps, because idrofilic it must to be encapsulated. The Raman spectra of registrated m RNA C19 vaccine not revealed graphene particle , but in literature it is reported that the direct tecchnique is no the best way to to detect well the nanolipids payload : so a negative results not imply this it not present inside the nanoparticle. Aim of this work is to investigate the manifacturing process of this biotechnological products submitting to the reseacrher an hypotesys of work than can explain all this pheneomena: the possible segregation of graphene inside the nanolipids. Great enphasys is given to the size , the chemico physical property like idrophilicity of the graphene particle versus the nanolipids used in some m RNA C19 vaccine, and the property of inside /outside this particles.