Background Hypotension during spinal anesthesia is one of the main concerns in cesarean section and there are very limited studies on the sequential administration of plain & hyperbaric bupivacaine in which the frequency of hypotension proves to be much less than either plain or hyperbaric bupivacaine alone. Objective To compare frequency of hypotension with hyperbaric vs sequential administration of plain & hyperbaric1bupivacaine1for spinal anesthesia in patients undergoing cesarean1section Methodology This Randomized controlled trial was conducted at Anesthesia Department, Ganga Ram Hospital, Lahore. Total 60 patients presenting to Obstetrics department from the Obstetrics operation theatre of SGRH, Lahore. Patients were randomly divided in two groups by using lottery method. Preoperative assessment was done a day prior to surgery. The patients of both groups were cannulated with two 18G intravenous lines and was preloaded with 10ml / kg of crystalloid solution. The baseline noninvasive blood pressures, heart rates & oxygen saturations of the patients were recorded. Patients were placed in sitting position & subarachnoid block was given at the L3-L4 or L4-L5 interspace. The patients in Group A was given 12 mg 0.75% hyperbaric bupivacaine Injection in 1.6 ml of solution and the patients in Group B received sequentially 6 mg 0.5% plain bupivacaine i.e 1.2ml of the drug and then 6 mg of 0.75% hyperbaric bupivacaine i.e 0.8 ml of the drug. Patients were immediately turned supine and the operating table was set to a horizontal position. Oxygen was given at a rate of 4 L min–1 & maternal blood pressure was noted, non-invasively every 1 min for 5 min after the subarachnoid block, and then every 5 minutes until the procedure was completed. Each episode of hypotension was noted as per operational definition. Results: Mean age of women in Group-A & B was 26.00±2.75 and 25.53±3.10 years. In Group-A 17(56.7%) women suffered from hypotension while in Group-B only 13(43.4%) women suffered from hypotension. in Group-A frequency of hypotension was high but it was not significant statistically. i.e. (p-value=0.302) Conclusion Results of this study demonstrate that with the use of Sequential Plain + Hyperbaric bupivacaine frequency of hypotension was less as compared to hyperbaric bupivacaine alone for spinal anesthesia in patients undergoing cesarean section.