Farming, food safety, and sustainable agriculture are trivial aspects in Africa that play significant roles to guarantee food security, public health, and environmental preservation. This paper aims at uncovering the challenges, limitations, and opportunities connected to farming, food safety, and sustainability in Africa. It highlights the interconnectedness of these issues and portrays the necessity for holistic approaches to be adopted as effective remedial solutions. I reveal that, farming in Africa ranges from small scale subsistence farming to larger commercial activities. Though agriculture is a vital source of income and employment for many Africans, significant setbacks like climatic mutations, soil degradation, limited access to natural and human resources, foodborne diseases, contamination, poor hygiene, limited storage facilities, lack of infrastructure, technology, etc., hinder development, productivity, and sustainability in most regions. I conclude by stating that, food safety concerns require multifaceted approaches and collective efforts from farmers, governments, consumers and other stakeholders charged with monitoring, strengthening, regulating, enhancing, and improving food handling practices. Environmental conservation can be ensured through sustainable agricultural practices such as, agroforestry, organic farming, conservation agriculture, and agro ecological principles expected to enhance productivity, biodiversity, improve soil health, limit the use of chemicals, and conserve water.