Alzheimer's disease is a neurological illness that primarily affects the elderly were gradual neuronal loss is observed. The hippocampal region of the brain is home to senile plaques, which contain deposits of beta-amyloidal protein, which is linked to the most prevalent type of dementia. The use of herbs has greatly improved global health. Despite the significant advancements in modern medicine over the past few years, plants continue to play a significant role in healthcare. The goal of the current investigation is to assess Solanum xanthocarpum (SX) in vivo using mice that have been given AD. The current study uses both in vitro and in vivo methods to examine the anti-Alzheimer's activity of the solanum xanthocarpum ethyl acetate extract (EAESX) Runway avoidance and the elevated plus maze experiments were used in in vivo investigations after inducing obesity, whereas modified Ellman's method was used in in vitro investigations. I.e. The increased lipid levels were decreased, and the rodent models likewise had positive outcomes. A histological analysis verified the recovery. Efficacy towards AD has been demonstrated by the plant extract (200 and 400 mg/kg). From the above results it is evident that ethyl acetate extract of solanum xanthocarpum posess obesity induced anti-alzheimer’s activity.