This study explores the pediculicidal of Urtica dioica (stinging nettle) leaf extracts against head lice. Two types of extracts were prepared: ethanolic, using a 95% ethanol maceration technique, and aqueous, through decoction. Adult head lice were collected with ethical approval and exposed to these solutions. Lice mortality was tracked at intervals up to 24 hours, while repellency was evaluated using a filter paper choice method. Results showed the ethanolic extract achieved complete mortality within 180 minutes, equaling permethrin, the standard control. It also induced 80% repellency, strongly discouraging lice from treated zones. The aqueous extract performed modestly, with a 60% mortality rate after 24 hours and 30% repellency. The markedly greater effectiveness of the ethanolic extract is attributed to its enhanced ability to solubilize active phytochemicals such as phenols, flavonoids, and terpenoids. Findings support previous research suggesting superior bioactivity in ethanolic herbal extracts and reinforce the traditional use of U. dioica as a medicinal plant. In summary, ethanolic U. dioica extract acts as a promising natural alternative for lice control. Validation in humans and further formulation studies are warranted to establish efficacy and safety.