Introduction: Transfusion of blood and blood products is similar to organ or tissue transplantation. Although it is risky, it is a life-saving treatment when necessary. Life expectancy at birth is increasing. Purpose: Developments have increased in the field of medicine, and in parallel with this, there has been a greater need for blood and blood products for increasing and changing surgeries. Since there is no other artificial product that can be used instead of blood, only human blood is still used. The aim of this study is to shed light on the open ethical issues between the donor and recipient of blood transfusion and to emphasize the necessity of the donor and recipient to benefit from health services effectively and ethically in accordance with the legislation in voluntary blood donation. Materials and Methods: Over the years, as a result of developments in the field of health, national awareness studies, and bitter experiences, the discovery of parameters to be determined before screening tests and the increase in knowledge and experience about blood-borne diseases have caused diseases transmitted through blood transfusion to become rare. However, there are still some open cases regarding this issue. Findings and Conclusion: Although healthcare professionals, especially healthcare workers, take all protective measures before every medical procedure in every intervention made to groups with some suspicious sexual behaviors and different sexual orientations; To evaluate whether transfusion is ethically appropriate in the transfusion of blood and blood products that are taken voluntarily and that do not constitute a legal obstacle for these groups to give unless they notify themselves (even though it is done in all tests), and to make arrangements for systems that meet the needs of these groups in the global world. is required.