Entrepreneurship Study Centres (ESCs) in African and Asian Universities are reshaping academic landscapes by fostering creativity, innovation, and entrepreneurial spirit among students and staff. These centres are critical in addressing unemployment and driving economic growth through structured entrepreneurial training. Despite the growing role of ESCs, their potential remains underexplored in mainstream academic discourse. Limited research exists on their direct impact on job creation, social transformation, and sustainable development. This study bridges that gap by highlighting their role in unlocking latent entrepreneurial talents. It examines how ESCs function as incubators for innovation, job creation, and economic transformation. The study investigates their effectiveness in equipping students with the skills, mentorship, and resources necessary to translate ideas into viable ventures. A qualitative and case-based approach was used, drawing from real-world evidence and success stories from African and Asian universities. The study analysed ESCs' mentorship programs, industry collaborations, and entrepreneurship education models. Findings reveal that ESCs significantly enhance entrepreneurial capacity, promote innovation through competitions, and facilitate knowledge transfer. However, challenges such as inadequate infrastructure, bureaucratic bottlenecks, and funding limitations hinder their full potential. ESCs represent a transformative force in higher education, unlocking economic and social potential. The study calls for an improved and consistent integration of entrepreneurship education into university curricula while advocating for sustained funding, policy incentives, and strategic partnerships to maximize their impact. Strengthening ESCs will drive Africa and Asia’s academic communities toward a future defined by innovation and sustainable enterprise.