The purpose of this study was to examine the belief in witchcraft and its effects on the stability of families in Mosocho Division, Kisii County which has persisted to exist. The study was guided by Marwick (1967) Theory of Social Accusation which argues that witchcraft accusations and allegations lead to social tension and hence breaks family relationships. The study applied descriptive survey research design conducted in Mosocho Division, Kisii County. Data was collected from Mosocho Division, Kisii County which comprises of seven locations. Data from respondents was collected through questionnaires and interviews. Pretesting of the questionnaires was undertaken to establish their reliability and validity. Proportionate and purposive sampling methods were used to collect data from a sample of Kisii elders, local government administration officials (chiefs and sub-chiefs), human rights activists and youths, that included both male and female participants with a total sample size consisting of 394 respondents. The respondent’s age, gender and period of residence were significant determinants. The collected data was analysed using Statistical Package for Social Sciences (SPSS) version 21.0 involving descriptive statistics for quantitative data. Qualitative data was analysed through content and thematic analysis aimed at consolidating thematic issues. The findings revealed that belief in witchcraft influences the stability of families. It is hoped that these findings through its recommendations will enable the community and local administration to come up with strategies and a platform that provide an opportunity for creating a more unified social order, based on family unity, and a more accommodating society devoid of witchcraft or its effects. address domestic violence, accompanied by the establishment of frameworks or guidelines within the church.