Nowadays, all financial institutions rely on ICT diffusion in gathering, processing, analyzing and providing information to meet customers’ needs. In an environment that is complex, competitive and dynamic, the diffusion of ICT in the highly information sensitive banking sector comes with mixed blessings especially in African context with under developed ICT tools. This article seeks to investigate the effects of information and communication technologies (ICT) diffusion on bank stability in Africa using a panel of 45 countries from 2004 to 2020. We employ the system GMM as well as a two step GMM method of estimation to check for robustness of the relationship between the variables. The results show a positive and significant relationship between ICT and bank stability. This implies that policies aimed at boosting ICT diffusion should not be neglected.