This study examines factors determining a bank's credit risk in Ghana, using bank-specific factors such as size, liquidity, profitability, and operational efficiency. Moreover, industry-specific factors such as finance sector expansion, inflation, and capitalization, and economic variables like inflation and GDP growth rate were also used. The study uses panel data from 23 commercial banks from 2010-2020. The study found that bank-specific determinants like bank size and operational efficiency significantly influence credit risk. However, profitability has a negative correlation, while industry-specific variables like financial sector development and capitalization positively affect credit risk. Macroeconomic variables like inflation also have a negative relationship with credit risk. Bank management should focus on these determinants to prevent NPLs and ensure proper monitoring and supervision.