The Dispiritedness is a prevalent ailment that often goes unnoticed and neglected. Many adverse consequences, such as heart toxicities, impotence, obesity, as well as insomnia, are commonly imposed by drug users. Around past ten years, their has been an increase in research in how herbal remedies might treat psychological issues. It was looked into whether solanum xanthocarpum has any antidepressant properties. Using tail suspension test (TST) models and locomotor activity by actophotometer, the anti-depressive potential of Solanum xanthocarpum ethyl acetate extract was examined. Different concentrations of Solanum xanthocarpum, such as 200 mg/kg and 400 mg/kg, were administered. Imipramine served as the benchmark. In comparison to the normal, diseased control, and standard groups, our investigation revealed the use of EAESX at higher concentration significantly reduced immobile phase in tail suspension and improved movement in actophotometer.