Anastrozole is a prescribed medication utilized for the treatment of hormone-dependent breast cancer, primarily in postmenopausal women. Administered orally once daily. Anastrozole inhibits the enzyme aromatase, which converts androgens into oestrogens. However, the administration of the medicine frequently results in adverse effects that vary based on dosage, including fatigue, diarrhea, hot flushes, nausea, headaches, and musculoskeletal discomfort. Anastrozole has been associated with additional adverse effects and increased bone loss. To mitigate the negative effects of anastrozole and ensure its effective distribution, it must be adhered to surfaces that are biocompatible and stable within the human body. The co-precipitation approach was employed to synthesized iron oxide nanoparticles, subsequently coated with silica by the Stober process. The synthesised Fe3O4@SiO2 nanocomposite was then coated with copolymer of acrylonitrile and acrylic acid (AN-co-AA) using microwave assisted polymerization. The Fe3O4@SiO2 @p(AN-co-AA) was analyzed using FTIR, EDX, and SEM techniques. The investigation examined how contact time, pH, drug quantity, and nanocomposite quantity influenced drug loading. The optimal adsorption (96.1%) occurred with 16 hour reaction duration, a pH of 4, anastrozole concentration of 20 µg/mL, and an adsorbent dosage of 10 mg.