This article examines best practices and recommendations for the nutritional management of patients affected by Monkeypox (MPOX) in the Democratic Republic of Congo (DRC). It emphasizes the disease's unique pathophysiological characteristics and the contextual challenges related to food security. A literature review was conducted using reliable databases such as PubMed, Google Scholar, Mendeley, and The Lancet. Studies published between 2000 and 2024 were analyzed for their relevance and methodological quality, focusing on nutrition and viral diseases, particularly Monkeypox. The findings highlight the significance of diets rich in proteins, vitamins, minerals, and essential fatty acids to strengthen patients' immunity. Nutritional strategies include supplementation, oral rehydration, and diets tailored to complications such as dehydration and hypercatabolism. Major challenges were also identified, such as limited access to nutritious food in the DRC, logistical constraints, and socioeconomic factors exacerbating malnutrition. Proper nutritional care enhances immune response, reduces complications, and strengthens the resilience of affected populations. The article provides practical recommendations for healthcare professionals and policymakers, emphasizing the need for locally adapted interventions to optimize nutritional management and support public health efforts in this complex context.