Background: Persons with a family history of colorectal cancer or other risk factors may need earlier or more frequent screening. Regular and early screening can significantly reduce colorectal cancer incidence and mortality by detecting and removing precancerous polyps or detecting cancer at an early, more treatable stage. Objective: To explore colorectal cancer (CRC) clinically, its impact on the population among aged patients in regional referral hospitals in Dar es Salaam - Tanazania. Methodology: The researchers used exploratory research design to underpin the work of (mziray et al 2024) since both teams worked in same facilities with similar indicators. Socio-demographic characteristics, knowledge, and awareness about CRC were assessed through observations, clinical test, in-depth interviews and confirmed cases of CRC that has been managed surgically and medically. Diagnostic interventions, including stool analysis, H. pylori antigen testing, and endoscopic interventions Risk assessment for CRC was conducted based on dietary habits and medical history. Conclusion: Socio-demographic analysis revealed limited awareness and knowledge about CRC, with notable disparities between positive and negative CRC cases. Comprehensive screening programs, coupled with increased knowledge dissemination, are crucial for early detection and prevention of CRC in Tanzania