Charcot-Marie-Tooth disease (CMT), also known as hereditary motor and sensory neuropathy or HMSN, is the most prevalent inherited neuromuscular ailment and one of the most prevalent groups of genetic disorders in humans. The primary clinical manifestation of CMT is comparatively uniform, characterised by distal limb muscular weakness and wasting, skeletal abnormalities such as pes cavus, and diminished or absent tendon reflexes. Although mild-to-moderate sensory abnormalities are conceivable, majority of patients do not experience clinical sensory problems. There are no previous studies conducted in Homoeopathy on CMT. The case reported was of a 25-year-old female born of consanguineous marriage, presented with weakness and tingling sensation of both upper and lower extremities with difficulty to stand and walk, tendency to fall while walking, inability to hold the neck without support, inability to sit without support and difficulty in swallowing for 6 months. The patient had conducted genetic testing and got diagnosed as CMT, Type 4H. After repertorization, on the basis of totality of symptoms, Phosphorus 30C was given and the medicine was repeated infrequently based on homoeopathic principles and physiotherapy sessions were also advised. During the course of the treatment potency was changed to 200C. Within 6 months of treatment the patient had marked improvement in her complaints and the positive causal attribution was assessed by MONARCH. The video evidence taken after the treatment along with the assessment report from physiotherapist have provided evidence for the improvement obtained from Phosphorus in CMT.