Telemedicine has revolutionised healthcare delivery by offering remote diagnosis and treatment options for various medical conditions. This innovative approach combines technology and medical expertise to provide convenient and efficient care to patients. By utilising telecommunication and digital platforms, healthcare professionals can now reach and treat individuals in remote areas, overcome barriers to access, and deliver timely interventions. This paper aims to explore the impact of telemedicine in the diagnosis and treatment of hypothyroidism, highlighting its benefits and potential challenges. Additionally, it will discuss the growing acceptance of telemedicine by patients and its implications for the future of medical practice.

In Cameroon, due to the implementation of the Test and Treat policy in 2016, antiretroviral therapy (ART) was generalized to all people affected by HIV. In people living with HIV (PLHIV) born HIV positive, although this treatment controls the plasma viral load of HIV, they are even more at risk of comorbidities compared to the general population. In addition, high levels of immune activation and inflammation persist despite control of HIV viremia, and associated to morbidities not ranking AIDS and the reactivation of other chronic viral infections, define a decline of the immune system called immunosenescence. Immunosenescence is appeared early in PLHIV born HIV positive but their follow-up is no different from those who acquired the infection late in life, leading to their early death unrelated to HIV infection. The general objective of this work was to identify biomarkers that could be included in the monitoring of PLHIV born HIV positive in order to predict the occurrence of immunosenescence. Between 2020 and 2022, we conducted a monocentric prospective study at Yaoundé on PLHIV born HIV positive from whom the socio-demographic profile was established. Biological parameters were measured in blood from two sampling periods (at recruitment and 12 months later), for the purpose of measure immune activation, inflammatory profile and markers of organ aging in order to bring out the combination of markers found relevant for the study of the immunosenescence of participants. It appears that, of the 20 biomarkers LTCD4+, LTCD8+, CD4/CD8 ratio, Platelets, Leukocytes, Monocytes, Neutrophils, Total leukocytes, Hemoglobin, TNF-α, IFN-γ, IL-2, IL-6, Creatinine, urea, AST, ALT, ALT/AST ratio, comorbidities, coinfections) described in the literature as being able to monitor immunosenescence, only 5 (LTCD4+, total leukocytes, platelets, IL-2 and IFN-γ) were found relevant to describe this state in our participants, parameters that can be measured with routine examinations (NFS, ELISA).

The objective of this study was to evaluate the efficacy of hands-on training using simulation-based techniques in basic neonatal resuscitation for nursing officers, employing a quasi-experimental pretest-posttest design. A non-probability purposive sampling method was utilized to select a sample of 39 nursing officers. The data analysis included both descriptive and inferential statistics, revealing a noteworthy improvement from the pretest assessment (33.2%) to the posttest assessment (75.38%). Sociodemographic data were collected to characterize the participants. The results of the paired t-test demonstrated a significant difference in the mean scores before (M = 6.6, SD = 3.5) and after (M = 15.1, SD = 2.5) the training intervention, with a p-value of less than .001, indicating a substantial enhancement in the participants' competency. These findings underscore the positive impact of the simulation-based training program on the nursing officers' proficiency in neonatal resuscitation. The study contributes to the understanding of simulation-based training effectiveness among nursing officers, underscoring the need for further research to explore diverse competencies and simulation methods in nurse training. A related systematic review on military nurses supports the efficacy of simulation-based interventions in enhancing various competencies. The conclusion emphasizes the necessity for additional research to expand the scope of simulation-based training for nurses and tailor methods to specific competency requirements.

One important component in the pathophysiology of diseases affecting the mucosa of the stomach is oxidative damage. oxygen species that react (ROS) are produced as metabolic byproducts of regular cellular activity. Catalase, glutathione peroxidase, and superoxide dismutase are the enzymes that help shield cells from the harmful effects of ROS. In response to UV light, `tobacco smoke, alcohol, NSAIDs medications, IR injury, persistent infections, and inflammatory diseases, ROS are generated. Redox signalling's disruption of normal cellular equilibrium can lead to cancer, neurological illnesses, and heart problems. Although the gastrointestinal (GI) tract produces ROS, little is known about how these molecules function in pathophysiology and the genesis of disease. We have covered certain medicinal plants in this review article that have been shown to have antiulcer action due to their antioxidant properties, as well as the function that free radicals play in ulcers that are scavenged by antioxidants found in the herbs. Antioxidants and oxidative stress play a complicated and multidimensional role in ulcers. Antioxidants are important preventive factors against ulcer development, however oxidative stress also plays a major role. To precisely understand the processes causing oxidative damage in ulcers and to create customised antioxidant-based treatments for ulcer management and prevention, more study is required.

This research rigorously investigates the wound-healing properties of Citrullus Colocynthis in a controlled experimental setting using animal models. Using a meticulous experimental methodology, we thoroughly examine the potential effectiveness of this plant-based substance as a catalyst for wound healing. As conduct a comprehensive examination, closely examining the complex processes and physiological reactions related to wound healing caused by Citrullus Colocynthis. Through the analysis of molecular complexities and the observation of physiological changes in animal models, our goal is to get a thorough knowledge of how this natural botanical substance influences the healing process. The significance of our discoveries goes beyond the boundaries of the laboratory, providing essential knowledge about the extensive domain of natural treatments for wound healing. With this study, our aim is to make a significant contribution to both scientific understanding and medicinal applications. The prospective uses of Citrullus Colocynthis in wound treatment might lead to novel techniques in healing, bridging the gap between traditional botanical knowledge and modern medical breakthroughs. This research seeks to enhance the discussion on wound healing procedures by exploring the connections between science and nature. The ultimate objective is to advance our overall comprehension and improve healthcare practices.

The clinical state known as diabetes is characterized by hyperglycaemia brought on by an absolute or relative insulin shortage. The incidence and prevalence of diabetes mellitus have increased significantly in recent decades. The pharmaceutical industry frequently uses in vitro techniques for large-scale production. Because they are more affordable and easier to develop, they are favoured over animal approaches. Reducing the amount of glucose produced and absorbed in the gastrointestinal tract by inhibiting enzymes that break down carbohydrates, such as α-amylase, α-glucosidase, and α-amylase inhibition, is one method of treating diabetes. The postprandial rise in blood glucose following a mixed carbohydrate diet can be considerably reduced by inhibiting the amylase and glucosidase enzymes involved in the digestion of carbohydrates. As a result, inhibition of these enzymes can be a crucial tactic for blood glucose control. We have covered several in vitro tests in this study, including the α-amylase, α-glucosidase, PTP-1B, insulin secretion, and glucose uptake assays. In-vivo methods are too costly for evaluating hits. To carry out the necessary tasks and achieve the corresponding goals, it is now essential to design and execute appropriate in-vitro screening techniques.