Globe (eyeball) luxation is a rare condition that can occur spontaneously or following trauma. Globe injuries, in general, can be classified into closed globe injuries and open globe injuries. Traumatic luxation occurs following high-velocity direct or indirect trauma, especially to the head and neck region. Trauma appears to be the most common cause of globe luxation, including incidents such as road traffic accidents, various forms of extreme sports, human and animal bites, domestic blunt or penetrating injuries, and self-inflicted injuries. Road traffic accidents seem to be the most frequent cause. Here is a description of anterior globe luxation post trauma in a case of road traffic accident. Patient presented in emergency within 2 hours of injury. With eyeball lying out of socket showing signs of ischemia. Emergency repositioning was carried in OT and eyeball was salvaged.

Background: Flavonoids are natural bioactive constituents in many plants. Fisetin (3,3′,4′,7-tetrahydroxyflavone), is a known key flavonoid found naturally in tomatoes, it has gathered interest worldwide for its potential prevention of chronic diseases.

Aim: Using simple and low-cost methods for the extraction, identification, and measurement of the concentration of naturally occurring fisetin in tomatoes.

Method: Two solvent mixtures were used for the extraction of fisetin, methanol/water (80:20) v/v and ethanol/water (50:50) v/v, followed by the measurement the total contents of phenols and flavonoids, in addition to the analysis of fisetin via thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC).

Results: The contents in the methanol extract (ME) and ethanol extract (EE) were 5.15g and 2.65g, respectively. Although there was no significant difference (p>0.05) in total phenolic content between the two extracts, total flavonoid content was found to be significantly increased in EE (p≤0.05). The presence of fisetin in the sample was confirmed by TLC, while HPLC showed higher values in EE (4.40 mg/g) than in ME (3.18 mg/g).

Conclusion: Ethanol is a more effective solvent for fisetin extraction, providing a simple and low-cost approach for recovering a good amount of fisetin from tomato.

Bone tumors in dogs are of high clinical relevance due to their aggressive biological behavior and significant impact on patients' quality of life. Given the therapeutic limitations imposed by anatomical location and tumor progression, multimodal approaches have been considered as a palliative management strategy. This study reports the case of a canine patient diagnosed with a thoracic vertebral neoplasm with an infiltrative process extending from T9 to T12, highlighting clinical findings, complementary examinations, therapeutic management, and clinical progression. Considering the inoperability of the neoplasm, the patient’s advanced age, and the owners’ priority to preserve quality of life, an integrative therapeutic protocol was implemented in association with conventional management using prednisolone. Treatment included injectable Viscum album, whose immunomodulatory and cytotoxic properties have been described in the literature, phytocannabinoids, acupuncture, and supportive care. During six months of follow-up, relevant clinical improvement was observed, including increased mobility, appetite, and overall behavior, as well as temporary stabilization of tumor progression based on clinical and complementary assessments. Subsequent progression resulted in the patient’s death, consistent with the aggressive nature of the neoplasm. These findings suggest that integrative veterinary medicine protocols may contribute to palliative management and maintenance of quality of life in cases where curative conventional interventions are not feasible.

The escalation prevalence of degenerative diseases is closely related to excessive exposure toward free radicals, can bring about oxidative stress. The roots of the orchid tail may contain novel bioactive sources that act as radical scavengers. The purpose of this study was to find out the antioxidant potential of foxtail orchid roots (Rhynchostylis retusa (L.) Blume). The method utilized to identify new antioxidant potential using bioassay-guided fractionation. The root simplicial powder was extracted with methanol and then partitioned into n-hexane, ethyl acetate, dichloromethane, and water. The antioxidant activity exhibited that the ethyl acetate extract had IC₅₀ value 33.47 µg/mL compared to the n-hexane, DCM, methanol, and water extracts. Then fractionated using colum chromatography led to collect fraction A with IC₅₀ value; 298,74 µg/mL, fraction B; IC₅₀ value 103.73 µg/mL and fraction C;  IC₅₀ value 45.41 µg/mL. The fraction C showed highest antioxidant activity compared to fraction A and B which contained tannin and phenolic may have a new lead compound for the development of antioxidants with a novel mechanism of action as an alternative raw material for phytopharmaceuticals.